In Democracy and the Claims of Nature, the leading thinkers in the fields of environmental, political, and social theory come together to discuss the tensions and sympathies of democratic ideals and environmental values. The prominent contributors reflect upon where we stand in our understanding of the relationship between democracy and the claims of nature. Democracy and the Claims of Nature bridges the gap between the often competing ideals of the two fields, leading to a greater understanding of each for the (...) other. (shrink)

This study in Bangladesh found that inter-cluster variation in the use of modern reversible methods of contraception was significantly attributable to the educational levels of the female family planning workers working in the clusters. Women belonging to clusters served by educated workers had a higher probability of being contraceptive users than those whose workers had only completed primary education. At the household level, important determinants of use were socioeconomic status and religion. At the individual level, the woman being the wife (...) of the household head and having some education were positively related to her being a user. The model also found that inter-household variation was significantly greater than inter-cluster variation. Finally, the study concludes that after controlling for various covariates at all three levels, the clusters do not have significantly different levels of use of modern reversible methods of contraception. There are, however, some special areas where contraceptive use is dramatically low, and these contribute significantly to the observed inter-cluster variation. (shrink)

Cook et al. reported a 97% scientific consensus on anthropogenic global warming (AGW), based on a study of 11,944 abstracts in peer-reviewed science journals. Powell claims that the Cook et al. methodology was flawed and that the true consensus is virtually unanimous at 99.99%. Powell’s method underestimates the level of disagreement because it relies on finding explicit rejection statements as well as the assumption that abstracts without a stated position endorse the consensus. Cook et al.’s survey of the papers’ authors (...) revealed that papers may express disagreement with AGW despite the absence of a rejection statement in the abstract. Surveys reveal a large gap between the public perception of the degree of scientific consensus on AGW and reality. We argue that it is the size of this gap, rather than the small difference between 97% and 99.99%, that matters in communicating the true state of scientific opinion to the public. (shrink)

Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

In December 2013, the Nonhuman Rights Project (NhRP) filed a petition for a common law writ of habeas corpus in the New York State Supreme Court on behalf of Tommy, a chimpanzee living alone in a cage in a shed in rural New York (Barlow, 2017). Under animal welfare laws, Tommy’s owners, the Laverys, were doing nothing illegal by keeping him in those conditions. Nonetheless, the NhRP argued that given the cognitive, social, and emotional capacities of chimpanzees, Tommy’s confinement constituted (...) a profound wrong that demanded remedy by the courts. Soon thereafter, the NhRP filed habeas corpus petitions on behalf of Kiko, another chimpanzee housed alone in Niagara Falls, and Hercules and Leo, two chimpanzees held in research facilities at Stony Brook University. Thus began the legal struggle to move these chimpanzees from captivity to a sanctuary, an effort that has led the NhRP to argue in multiple courts before multiple judges. The central point of contention has been whether Tommy, Kiko, Hercules, and Leo have legal rights. To date, no judge has been willing to issue a writ of habeas corpus on their behalf. Such a ruling would mean that these chimpanzees have rights that confinement might violate. Instead, the judges have argued that chimpanzees cannot be bearers of legal rights because they are not, and cannot be persons. In this book we argue that chimpanzees are persons because they are autonomous. (shrink)

We have synthesized a 582,970-base pair Mycoplasma genitalium genome. This synthetic genome, named M. genitalium JCVI-1.0, contains all the genes of wild-type M. genitalium G37 except MG408, which was disrupted by an antibiotic marker to block pathogenicity and to allow for selection. To identify the genome as synthetic, we inserted "watermarks" at intergenic sites known to tolerate transposon insertions. Overlapping "cassettes" of 5 to 7 kilobases (kb), assembled from chemically synthesized oligonucleotides, were joined by in vitro recombination to produce intermediate (...) assemblies of approximately 24 kb, 72 kb ("1/8 genome"), and 144 kb ("1/4 genome"), which were all cloned as bacterial artificial chromosomes in Escherichia coli. Most of these intermediate clones were sequenced, and clones of all four 1/4 genomes with the correct sequence were identified. The complete synthetic genome was assembled by transformation-associated recombination cloning in the yeast Saccharomyces cerevisiae, then isolated and sequenced. A clone with the correct sequence was identified. The methods described here will be generally useful for constructing large DNA molecules from chemically synthesized pieces and also from combinations of natural and synthetic DNA segments. 10.1126/science.1151721. (shrink)

We submit this brief in support of the Nonhuman Rights Project’s efforts to secure habeas corpus relief for the elephant named Happy. We reject arbitrary distinctions that deny adequate protections to other animals who share with protected humans relevantly similar vulnerabilities to harms and relevantly similar interests in avoiding such harms. We strongly urge this Court, in keeping with the best philosophical standards of rational judgment and ethical standards of justice, to recognize that, as a nonhuman person, Happy should be (...) released from her current confinement and transferred to an appropriate elephant sanctuary, pursuant to habeas corpus. (shrink)

The authors of the concept Health-Related Digital Autonomy have laid the first building block to examine the interactions between artificial intelligence, social media, and depression f...

The mechanisms responsible for the fine tuning of development, where the wildtype phenotype is reproduced with high fidelity, are not well understood. The difficulty in approaching this problem is the identification of mutant phenotypes indicative of a defect in these fine‐tuning control mechanisms. Evolutionary biologists have used asymmetry as a measure of developmental homeostasis. The rationale for this was that, since the same genome controls the development of the left and right sides of a bilaterally symmetrical organism, departures from symmetry (...) can be used to measure genetic or environmental perturbations. This paper examines the relationship between asymmtry and resistance to organophosphorous insecticides in the Australian sheep blowfly, Lucilia cuprina. A resistance gene, Rop‐1, which encodes a carboxylesterase enzyme, also confers a significant increase in asymmetry. Continued exposure of resistant populations to insecticide has selected a dominant suppressor of the asymmetry phenotype. Genetic evidence indicates that the modifier is the L. cuprina Notch homologue. (shrink)

In the conclusion to this multi-part article I first review the discussions carried out around the six essential questions in psychiatric diagnosis – the position taken by Allen Frances on each question, the commentaries on the respective question along with Frances’ responses to the commentaries, and my own view of the multiple discussions. In this review I emphasize that the core question is the first – what is the nature of psychiatric illness – and that in some manner all further (...) questions follow from the first. Following this review I attempt to move the discussion forward, addressing the first question from the perspectives of natural kind analysis and complexity analysis. This reflection leads toward a view of psychiatric disorders – and future nosologies – as far more complex and uncertain than we have imagined. (shrink)

What job should authorities give to review boards? We are grateful to Soren Holm, Rosamond Rhodes, Julian Savulescu and G Owen Schaefer for their thoughtful commentaries on our answer.1–4 Here we add to the discussion. Let us summarise the claims for which we argued.5 Relevant authorities can task boards with review for consistency with duly established code, thereby making code-consistent activities apt for approval and code-inconsistent activities apt for rejection. They can instead task boards with review for ethical acceptability, making (...) ethically acceptable activities apt for approval and ethically unacceptable activities apt for rejection. For every proposal a board might consider, these two different jobs establish different review bases, and their approvals and rejections also sometimes conflict. Some international and national statements require ECR, others instead require CCR, and others again seem either to require both or just to run the two together. Those responsible for these statements should make them clearer and better aligned here. For reasons of practicality, publicity and separation of powers, authorities do better to task boards with CCR and not ECR. These arguments also count against establishing any code with content that in effect collapses CCR into ECR. If our arguments withstand robust scrutiny, authorities should also remove ‘ethics’ and cognate terms from the names of these boards and their review activities and emphasise code expertise not ethics expertise in the required skill sets of boards. Our article noted that ‘ethical considerations informed the genesis of these boards and express their aspirations’. Rhodes similarly notes: ‘the authors and endorsers of research ethics codes, declarations and regulations … articulating the ethical standards for conducting human subject research’ and ‘This framework embeds the ethical parameters of human subject research into the moral missions of institutions’. Schaefer too …. (shrink)

BackgroundHIV prevention research in resource-limited countries is associated with a variety of ethical dilemmas. Key amongst these is the question of what constitutes an appropriate standard of health care (SoC) for participants in HIV prevention trials. This paper describes a community-focused approach to develop a locally-appropriate SoC in the context of a phase III vaginal microbicide trial in Mwanza City, northwest Tanzania.MethodsA mobile community-based sexual and reproductive health service for women working as informal food vendors or in traditional and modern (...) bars, restaurants, hotels and guesthouses has been established in 10 city wards. Wards were divided into geographical clusters and community representatives elected at cluster and ward level. A city-level Community Advisory Committee (CAC) with representatives from each ward has been established. Workshops and community meetings at ward and city-level have explored project-related concerns using tools adapted from participatory learning and action techniques e.g. chapati diagrams, pair-wise ranking. Secondary stakeholders representing local public-sector and non-governmental health and social care providers have formed a trial Stakeholders' Advisory Group (SAG), which includes two CAC representatives.ResultsKey recommendations from participatory community workshops, CAC and SAG meetings conducted in the first year of the trial relate to the quality and range of clinic services provided at study clinics as well as broader standard of care issues. Recommendations have included streamlining clinic services to reduce waiting times, expanding services to include the children and spouses of participants and providing care for common local conditions such as malaria. Participants, community representatives and stakeholders felt there was an ethical obligation to ensure effective access to antiretroviral drugs and to provide supportive community-based care for women identified as HIV positive during the trial. This obligation includes ensuring sustainable, post-trial access to these services. Post-trial access to an effective vaginal microbicide was also felt to be a moral imperative.ConclusionParticipatory methodologies enabled effective partnerships between researchers, participant representatives and community stakeholders to be developed and facilitated local dialogue and consensus on what constitutes a locally-appropriate standard of care in the context of a vaginal microbicide trial in this setting.Trial registrationCurrent Controlled Trials ISRCTN64716212. (shrink)

What does it mean to consider the world of AI through a Christian lens? Rapid developments in AI continue to reshape society, raising new ethical questions and challenging our understanding of the human person. Encountering Artificial Intelligence draws on Pope Francis’ discussion of a culture of encounter and broader themes in Catholic social thought in order to examine how current AI applications affect human relationships in various social spheres and offers concrete recommendations for better implementation. The document also explores questions (...) regarding personhood, consciousness, and the kinds of relationships humans might have with even the most advanced AI. Through these discussions, this book investigates the theoretical and practical challenges to interpersonal encounter raised by the age of AI. (AI Research Group for the Centre for Digital Culture of the Dicastery of Culture and Education of the Holy See). (shrink)

In face of the multiple controversies surrounding the DSM process in general and the development of DSM-5 in particular, we have organized a discussion around what we consider six essential questions in further work on the DSM. The six questions involve: 1) the nature of a mental disorder; 2) the definition of mental disorder; 3) the issue of whether, in the current state of psychiatric science, DSM-5 should assume a cautious, conservative posture or an assertive, transformative posture; 4) the role (...) of pragmatic considerations in the construction of DSM-5; 5) the issue of utility of the DSM – whether DSM-III and IV have been designed more for clinicians or researchers, and how this conflict should be dealt with in the new manual; and 6) the possibility and advisability, given all the problems with DSM-III and IV, of designing a different diagnostic system. Part 1 of this article took up the first two questions. Part 2 took up the second two questions. Part 3 now deals with Questions 5 & 6. Question 5 confronts the issue of utility, whether the manual design of DSM-III and IV favors clinicians or researchers, and what that means for DSM-5. Our final question, Question 6, takes up a concluding issue, whether the acknowledged problems with the earlier DSMs warrants a significant overhaul of DSM-5 and future manuals. As in Parts 1 & 2 of this article, the general introduction, as well as the introductions and conclusions for the specific questions, are written by James Phillips, and the responses to commentaries are written by Allen Frances. (shrink)

Natural environments differ from artworks in two ways: (a) they are surroundings filled with objects, processes, and the observer, (b) they are natural, not intentionally created to be appreciated. I show that this serious problem for accounts of aesthetic appreciation of nature has led many thinkers in environmental aesthetics (e.g., Carlson and Rolston) to claim that appreciators should be actively engaged with a natural environment. But how? One suggestion has been that appreciators play the role of creative performers in the (...) arts. I explore this analogy, distinguishing three different kinds of performance. I argue that none is a good fit as a model of nature appreciation but that the analogy sheds considerable light on environmental art, especially the site-specific artworks of Andy Goldsworthy. (shrink)

In face of the multiple controversies surrounding the DSM process in general and the development of DSM-5 in particular, we have organized a discussion around what we consider six essential questions in further work on the DSM. The six questions involve: 1) the nature of a mental disorder; 2) the definition of mental disorder; 3) the issue of whether, in the current state of psychiatric science, DSM-5 should assume a cautious, conservative posture or an assertive, transformative posture; 4) the role (...) of pragmatic considerations in the construction of DSM-5; 5) the issue of utility of the DSM - whether DSM-III and IV have been designed more for clinicians or researchers, and how this conflict should be dealt with in the new manual; and 6) the possibility and advisability, given all the problems with DSM-III and IV, of designing a different diagnostic system. Part I of this article took up the first two questions. Part II will take up the second two questions. Question 3 deals with the question as to whether DSM-V should assume a conservative or assertive posture in making changes from DSM-IV. That question in turn breaks down into discussion of diagnoses that depend on, and aim toward, empirical, scientific validation, and diagnoses that are more value-laden and less amenable to scientific validation. Question 4 takes up the role of pragmatic consideration in a psychiatric nosology, whether the purely empirical considerations need to be tempered by considerations of practical consequence. As in Part 1 of this article, the general introduction, as well as the introductions and conclusions for the specific questions, are written by James Phillips, and the responses to commentaries are written by Allen Frances. (shrink)

In face of the multiple controversies surrounding the DSM process in general and the development of DSM-5 in particular, we have organized a discussion around what we consider six essential questions in further work on the DSM. The six questions involve: 1) the nature of a mental disorder; 2) the definition of mental disorder; 3) the issue of whether, in the current state of psychiatric science, DSM-5 should assume a cautious, conservative posture or an assertive, transformative posture; 4) the role (...) of pragmatic considerations in the construction of DSM-5; 5) the issue of utility of the DSM - whether DSM-III and IV have been designed more for clinicians or researchers, and how this conflict should be dealt with in the new manual; and 6) the possibility and advisability, given all the problems with DSM-III and IV, of designing a different diagnostic system. Part I of this article will take up the first two questions. With the first question, invited commentators express a range of opinion regarding the nature of psychiatric disorders, loosely divided into a realist position that the diagnostic categories represent real diseases that we can accurately name and know with our perceptual abilities, a middle, nominalist position that psychiatric disorders do exist in the real world but that our diagnostic categories are constructs that may or may not accurately represent the disorders out there, and finally a purely constructivist position that the diagnostic categories are simply constructs with no evidence of psychiatric disorders in the real world. The second question again offers a range of opinion as to how we should define a mental or psychiatric disorder, including the possibility that we should not try to formulate a definition. The general introduction, as well as the introductions and conclusions for the specific questions, are written by James Phillips, and the responses to commentaries are written by Allen Frances. (shrink)

Many philosophers of science believe that empirical psychology can contribute little to the philosophical investigation of explanations. They take this to be shown by the fact that certain explanations fail to elicit any relevant psychological events (e.g., familiarity, insight, intelligibility, etc.). We report results from a study suggesting that, at least among those with extensive science training, a capacity to render an event intelligible is considered a requirement for explanation. We also investigate for whom explanations must be capable of rendering (...) events intelligible and whether or not accuracy is also viewed as a requirement. (shrink)

This essay reviews John Gardner’s recent books, From Personal Life to Private Law, and Torts and Other Wrongs. Both books offer profound insights into private law’s concerns with justice and our reasons for action. The essay focuses on Gardner’s continuity thesis, and in particular on his idea that a third party may act on behalf of a wrongdoer as her delegee. Three settings are considered. First, I will discuss settings in which the state or another third party acts to (...) remedy a wrong without the wrongdoer’s consent. Second, I will review settings in which the legal remedies at issue – e.g., general damages or punitive damages – may not fit well with the idea that the state is acting on behalf of a wrongdoer. Third, I will analyze settings in which the state may be acting on behalf of right holders, yet still be concerned with the continuity thesis. Assessing each of these contexts offers further insights into the purpose of private law remedies. (shrink)

Are the characteristics and relationships among spatio-temporal entities "real" or are they simply conventional terms that note similarities among things in the world but lack any reality of their own? Or if they are real, what sort of reality do they have? Do we live in a world of causes and effects, or is this relation a useful contrivance for our convenience? What is the nature of this "I" that we invoke when referring to ourselves? Is it body? Mind? Both? (...) Neither? And once its nature is understood, what can be said of the choices it makes? Are they really ours, freely made by an independent will? Or is each choice determined more by the internal makeup of the "I" we happen to be and the social/environmental circumstances in which this "I" finds itself, rather than by any act of will? But if each of us "could not have chosen otherwise" than we have, are we no better than the machines we construct? Then again, maybe some of our more advanced machines should be considered conscious entities? Introduction to Metaphysics: The Fundamental Questions presents these and other intriguing questions, many of which have challenged philosophers from antiquity to the present in their efforts to speculate on the nature of what is real. Often filled with twists and turns, dark corners and hidden recesses, this journey of discovery is an exciting excursion into the depths of human understanding. As guides for this intellectual journey editor Andrew Schoedinger has chosen an impressive array of creative and thought-provoking philosophers: Peter Abelard, Aristotle, Renford Bambrough, George Berkeley, Joseph Butler, Rudolf Carnap, Roderick Chisholm, R.G. Collingwood, Arthur Danto, Donald Davidson, Rene Descartes, C.J. Ducasse, Alvin I. Goldman, Keith Gunderson, David Hume, John Locke, Alasdair MacIntyre, A.I. Melden, John Stuart Mill, D.F. Pears, Hilary Putnam, Anthony Quinton, Bertrand Russell, Michael Scriven, Sydney Shoemaker, P. F. Strawson, Richard Taylor, and others. This volume is a unique invitation to join a distinguished group of theorists as they tackle tough questions concerning the existence of universals, the nature of causation, understanding personal identity, the tangled web of free will, and the challenges posed by the advent of artificial intelligence. (shrink)

In Rescuing Justice and Equality , G. A. Cohen reiterates his critique of John Rawls's difference principle as a justification for inequality-generating incentives, and also argues that Rawls's ambition to provide a constructivist defence of the first principles of justice is doomed. Cohen's arguments also suggest a natural response to my earlier attempt to defend the basic structure objection to Cohen's critique, which I term the alien factors reply. This paper criticises the reply, and Cohen's more general argument against (...) Rawls's constructivism. 1. (shrink)

This chapter examines the contribution of philosopher Isaac Newton to early modern British philosophy, whose work, it suggests, can be divided into several stages. These include his works on mathematics in the 1660s, experimental optics in the 1670s, natural philosophy and the publication of his Principia mathematica in the 1680s, and his friendship and philosophical exchanges with other philosophers, including John Locke, G.W. Leibniz, and Richard Bentley in the 1690s. The chapter also highlights the influence of Locke and Francis (...) Bacon on the works of Newton. (shrink)

Philosophical methodology is the central focus of pragmatism’s founding documents. The early works of Peirce, James, and Dewey examine methodological questions such as ‘how do we make philosophical ideas clear?’, ‘what is the best method for fixing belief?’ and ‘how do we know whether a philosophical question is answerable?’. Thus, many consider pragmatism inherently methodological – as a metaphilosophy, a view about how philosophy should or must be done (e.g. Talisse 2017). Any summary of pragmatist methods is therefore a summary (...) of pragmatism itself. Given such an impossibly broad remit, this chapter does only three things. First, it provides four broad claims common to pragmatist approaches to philosophical methodology, claims reflecting its underlying theory of inquiry. Second, it briefly examines three core pragmatist methods – for conceptual clarification, for fixing belief, and for settling or dissolving philosophical disputes. Third, it briefly describes differences between the Classical figures regarding each method. This is merely a brief sketch – the reader should consider all entries in this volume relevant to pragmatism qua philosophical method. (shrink)

Conflicting answers to the question of what principles of justice are for may generate very different ways of theorizing about justice. Indeed divergent answers to it are at the heart of G. A. Cohen's disagreement with John Rawls. Cohen thinks that the roots of this disagreement lie in the constructivist method that Rawls employs, which mistakenly treats the principles that emerge from a procedure that involves factual assumptions as ultimate principles of justice. But I argue that even if Rawls (...) were to abandon his constructivism, and to accept Cohen's argument that ultimate principles of justice are not grounded directly in any facts, their divergent views concerning the proper role of principles of justice would lead them to different conclusions. I contend that even if ultimate principles of justice are not directly grounded in any facts, the role that principles of justice are needed to play may mean that their justification depends upon facts about what is feasible and facts about what is burdensome to people. Contrary to what Cohen maintains, being dependent on the facts in this manner does not preclude a principle from being ultimate; nor do principles which have this sort of dependence on the facts necessarily combine justice with other values in a way that must lead to conflation. (shrink)

In recent discussions of moral responsibility, two claims have generated considerable attention: 1) a complete account of responsibility cannot ignore the agent’s personal history prior to the time of action; and 2) an agent’s responsibility is not determined solely by whether certain objective facts about the agent obtain (e.g., whether he/she was free of physical coercion) but also by whether, subjectively, the agent views him/herself in a particular way. John Martin Fischer and Mark Ravizza defend these claims and combine (...) them in a novel manner. They argue that responsibility for an action requires that the agent—at some prior time—have taken responsibility for the kind of mechanism, or process, which produced the action (e.g., practical reason). The notion of taking responsibility is then understood subjectively, requiring that the agent believe it appropriate for others to hold him/her responsible for actions produced by that kind of mechanism. I explore how best to understand the role(s) played by the notion of taking responsibility in Fischer and Ravizza’s account and then argue that being responsible for an action does not require that one have taken responsibility in the subjective sense. That is, being responsible is not a matter of believing oneself to be so. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Dimensions of Agency in Lincoln’s Second InauguralAndrew C. HansenSix days before he delivered his Second Inaugural Address, Abraham Lincoln strode into his White House office. Greeting him were G. B. Lincoln, John A. Bingham, and Francis Carpenter, the last of whom had been living with Lincoln in the White House for six months, painting a portrait of the president reading the Emancipation Proclamation to the cabinet. It is (...) Carpenter's delineation of the president's entrance that contains the "only known description of the preliminaries of the Second Inaugural" (Barondess 1954, 62). "Mr. Lincoln came in through the side passage which had lately been constructed," Carpenter writes, "holding in his hand a roll of manuscripts." Lincoln turned to his guests and quipped, "Lots of wisdom in that document, I suspect; it is what will be called my 'second inaugural' " (quoted in Barondess, 62).The content and modesty of Carpenter's description of the "preliminaries of the Second Inaugural" give the rhetorical critic a telling preview of what might be discovered in a reading of Lincoln's composition of that manuscript. The understatement in the length and simplicity of the address subtly and poignantly charms the reader. And there is "lots of wisdom" in the Second Inaugural: along with the Gettysburg Address, it contains the words of Lincoln that most abide. In a letter to an admiring Thurow Weed, who had penned Lincoln that his inaugural was "the neatest but the most pregnant and effective use to which the English Language was ever put," Lincoln wrote that he "expected" the Second Inaugural to "wear as well as—perhaps better than—anything I have ever produced" (quoted in Barondess 1954, 78).Underscoring Lincoln's perspicacity when he wrote to Weed that he "expected" the speech to "wear well," Carl Schulz's designation of the address as a "sacred poem" and the frequency with which that epithet is quoted by other critics confirm Lincoln's assessment of the oratorical endurance [End Page 223] of the piece. The estimation of the rhetorical durability of the address is perhaps best proven by its ability to withstand the polemics of its detractors, both immediately after its delivery and in successive generations, and the encomia of its admirers, both the obscure journalists and the renowned poets.1 Lately, only praise surrounds the Second Inaugural. Ronald C. White's thorough overview of the Second Inaugural's basic stylistic characteristics and how the oration resonates within Lincoln's social, political, and intellectual context is modestly entitled Lincoln's Greatest Speech (2002). In the last line of Lincoln at Gettysburg, Wills concludes that the Second Inaugural "is the only speech worthy to stand with" the Gettysburg Address (1992, 189) and later argues in the Atlantic Monthly that Lincoln "was at the peak of his creativity when he wrote the Second Inaugural Address" (1999, 70). The Second Inaugural seemingly speaks beyond its content and situation.Contained within the aura of adoration that surrounds the Second Inaugural is a significant charge to the rhetorical critic: what is it particularly about the address that sustains its agency and permits it to escape the evanescence accorded to most rhetorical efforts? When the agency of discourse helps to eliminate or extenuate the immediate exigency that calls forth that speech, it usually becomes remanded to the annals of history and is examined by the public or by scholars only when that historical nidus forces itself back upon the public's or the scholar's attention. The speech is exhausted by its situation and swallowed by its surrounding and future events. There are, however, those speeches like the Gettysburg Address and the Second Inaugural that practice their persuasion on audiences beyond the immediate exigency. They persist, they talk to us still, and their agency endures. Why is this true of Lincoln's Second Inaugural? This is the question that motivates my close reading of Lincoln's speech; and, as I hope to demonstrate, it is only through a close reading that such a question even makes sense. After explicating the scholarship that the Second Inaugural has generated and the critical assumptions that drive my close textual analysis, the essay will proceed with the work... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Dei Filius IV:On the Development of DogmaAndrew MeszarosIntroductionHistorically, it is indisputable that the intention of the latter part of chapter 4 of Dei Filius was to restate the substantial immutability of the deposit of faith, not for the sake of rejecting doctrinal development, but for the sake of establishing parameters for a certain profectus fidei—progress or development in the faith—which no Catholic theologian doubted, not even nineteenth-century neo-Scholastics. Then-contemporary (...) (e.g., John Henry Newman and the Tübingen school) and subsequent (e.g., Yves Congar and Henri de Lubac) theologians' theories that were more thoroughly worked out presupposed this immutability.The argument here is simple: Dei Filius's teaching on the immutability of dogma not only did serve as the necessary foundation for any sound (i.e., Catholic) theory of doctrinal development, but continues to do so. While the teaching of Dei Filius itself is limited and incomplete, it is essential. Furthermore, its key feature of dogmatic immutability is not compromised by even the most dramatic of doctrinal developments.To establish the ongoing relevance of Dei Filius for contemporary discussions on doctrinal development, I will first draw out certain key similarities between the nineteenth-century, modernist, and contemporary contexts. This will be followed by a presentation of the relevant portions of Dei Filius. Finally, in the longest section, I will discuss what is at stake in the teaching of Dei Filius and offer some different examples of how doctrines develop in ways that uphold the fundamental-theological principle laid out [End Page 909] in Dei Filius: namely, that all doctrinal development is homogenous with, or in continuity with, the deposit of faith.Anton Günther and Theology TodayWe can identify two major factors that led to the Vatican Council having to address dogmatic development. The first, and perhaps most important, factor is the implication that Anton Günther's (1783–1863) understanding of faith and reason had on dogma and its immutability. The second factor is simply the fact that, in the midst of these pervasive philosophical and theological disputes over faith and reason, Pius IX not only managed to define the Immaculate Conception as dogma, but did so by papal definition: the 1854 definition was the freshest example of what would later be defined in 1870.1 A brief examination of the thought of Günther will help us better understand why the paragraph on development (i.e., the immutability and progress of dogma) pertains to the faith–reason relationship and, hence, appears in the fourth chapter. 2Günther's major concern is a noble one: namely, to respond to the Kantian critique of supernatural religion. To do so, he sees it as necessary not only to defend rationally but also to explain rationally—according to the philosophical systems of Schelling and Hegel—Christian dogma. Günther is no brash and pure rationalist. He believes in the history of supernatural revelation. He acknowledges that reason alone could never discover supernaturally revealed truths; but, as a so-called semi-rationalist, he believes that, once made known to it, reason can then penetrate and, indeed, prove these revealed truths.3 [End Page 910]But if revealed mysteries are discoverable by human reason, then those same mysteries have to be interpreted in such a way that is, indeed, within the reach of reason using its proper resources.4 Not Scholasticism but German idealism—especially its category of self-consciousness—was Günther's vehicle for giving an account of the faith. Such a re-interpretation of Christian dogma according idealism's categories naturally alters the original understanding of that dogma. But for Günther, this reinterpretation is necessary if revelation is to be accessible to reason.So, for example, because modern psychology cannot make sense of a distinction between "person" and "nature" that is not coterminous, we must conclude, against Ephesus, that Christ is in fact a unity of two persons. Nor, for that matter, is the human person a composite of body and soul as defined by the Council of Vienne (1311–1312). Because God is self-conscious spirit, there is a process of trebling in God that tends toward... (shrink)

It is generally unquestioned that human subjects research review boards should assess the ethical acceptability of protocols. It says so right on the tin, after all: they are explicitly called research ethics committees in the UK. But it is precisely those sorts of unchallenged assumptions that should, from time to time, be assessed and critiqued, in case they are in fact unfounded. John Stuart Mill's objection to suppressers of dissent is instructive here: “If the opinion is right, they are (...) deprived of the opportunity of exchanging error for truth: if wrong, they lose, what is almost as great a benefit, the clearer perception and livelier impression of truth, produced by its collision with error”.1 Andrew Moore and Andrew Donnelly's compelling article, “The job of ‘ethics committees’”, is just this sort of challenge to conventional wisdom, a rejection of the notion that review boards should be considering ethical matters at all.2 If true, we should be substantially reforming our research ethics policies. And if false, rebuttals would help strengthen and ground the otherwise unquestioned assumption of the role of ethics committees. As it happens, I will argue that their critiques fall into the second category. While mistaken, they present a valuable opportunity to clarify the role of ethics committees and their relationship to relevant codes. In particular, I will defend a hybrid account where codes have strict primacy, but leave significant room for review boards …. (shrink)

Oxidised bases, such as 8-oxo-guanine, occur in cellular DNA as a result of attack by oxygen free radicals. The cancer-protective effect of vegetables and fruit is attributed to the ability of antioxidants in them to scavenge free radicals, preventing DNA damage and subsequent mutation. Antioxidant supplements (e.g., β-carotene, vitamin C) increase the resistance of lymphocytes to oxidative damage, and a negative correlation is seen between antioxidant concentrations in tissues and oxidised bases in DNA. Large-scale intervention trials with β-carotene have, however, (...) led to increases in cancer. Recent measurements of the frequency of oxidised DNA bases indicate that earlier estimates were greatly exaggerated; there may be only a few thousand 8-oxo-guanines per cell. Convincing evidence for mutations resulting from oxidative damage, in tumours or cultured cells, is lacking. It seems that efficient antioxidant defences together with DNA repair maintain a steady-state level of damage representing minimal risk to cell or organism. BioEssays 21:238–246, 1999. © 1999 John Wiley & Sons, Inc. (shrink)

G. A. Cohen argues that Rawls’s difference principle is incompatible with his endorsement of incentives inequality—higher pay for certain professions is just when that pay benefits everyone. Cohen concludes that Rawls must reject both incentives inequality and ‘institutionalism’—the view that egalitarian principles, including the difference principle, apply exclusively to social institutions. I argue that the premises of Cohen’s ‘internal criticism’ of Rawls require rejecting two important parts of his theory: a ‘subjective circumstance of justice’ and a ‘shared conception of justice’. (...) These are important parts of Rawls’s ‘constructivism’. Constructivism is the view that a conception of justice is the solution to a practical interaction problem and is solved in part by examining the facts of the problem. Thus, an upshot of my arguments is that this Cohen/Rawls dispute reduces to another dispute over ‘constructivism’. (shrink)

The Palgrave Handbook of Practical Animal Ethics is a recent addition to anthologies in the field, joining The Oxford Handbook of Animal Ethics, and The Routledge Handbook of Animal Ethics. Edited by Andrew Linzey and Clair Linzey of the Oxford Centre for Animal Ethics, the book boasts more than 30 contributors, many of them philosophers, but also including sociologists, scientists, theologians, lawyers, psychologists, and animal advocates. The editors were intentionally multidisciplinary in their approach, noting that “there is currently no (...) book series that is a focus for multidisciplinary research in the field,” and calling attention to the need not only for philosophical inquiry into what we owe animals, but also into the “social, legal, cultural, religious and political” influences that “legitimate animal abuse” (p. viii).The book is divided up into four sections: “The Ethics of Control,” “The Ethics of Captivity,” “The Ethics of Killing,” and “The Ethics of Causing Suffering.” Each of these sections includes an editorial introduction and multiple entries spanning diverse issues, including animal research, animal agriculture, hunting, fishing, zoos, the role of animals in religion, the role of language in structuring thought about nonhuman animals, and others. Similarly, the chapters span issues affecting many species, including farmed animals, fish, deer, elephants, whales and dolphins, rodents, companion animals (e.g., dogs and cats), and others.While the book is billed as a “practical” handbook of animal ethics, it does wade into some conceptual territory, tackling such issues as the ethical permissibility of confining and controlling animals, the question of whether (painless) death harms nonhuman animals, and the comparative wrongness of killing humans and nonhuman animals. This said, it largely stays away from more detailed discussion of normative ethical theory and the moral standing of nonhuman animals, focusing instead on the specific ways that humans treat nonhuman animals. In focusing more on practical than theoretical ethics, the Palgrave Handbook of Practical Animal Ethics both complements and differentiates itself from some other anthologies in the field.The book has several strengths to recommend it, the first being the logic of its organization. The ethically problematic aspects of humans’ treatment of nonhuman animals frequently map onto one or more of the categories of causing suffering, killing, and confining. The organization of chapters under these section headings helps to provide a rational structure to the text, as well as an easy way for the reader to navigate which sections they would like to tackle first (although there is some overlap between sections). With this, the explicit and sustained focus on the ethics of control (section 1) is a welcome and differentiating feature of the text. Much prior work in animal ethics has addressed questions of harming and killing animals, but the ethical permissibility of control per se has received comparatively lesser attention.The multidisciplinary nature of the book is also a selling point. In any anthology on animal ethics, the reader can expect entries from academic philosophers, but the book's inclusion of empirical scientific reviews, sociological and legal analyses, and work in discourse analysis are strengths. One danger in focusing exclusively on what we ought to think and do is that it ignores the influences on how we actually think and act. Many of the book's entries address these influences and thus round out the normative analysis.The middle two sections of the book seem most successful to this reviewer. The section on the ethics of killing contains two well-argued conceptual chapters, coupled with practical analyses of fishing, deer hunting, and religious perspectives on killing nonhuman animals. While animal research and animal agriculture are not directly addressed in this section, the conceptual arguments can be applied to the killing of nonhuman animals in these contexts. The section on the ethics of captivity is not as conceptually strong but contains excellent empirical chapters on the welfare of elephants, whales, and dolphins in captivity. Prior work in normative ethics has established how confinement can be harmful to nonhuman animals by directly causing suffering or depriving them of opportunities for satisfaction (see, e.g., DeGrazia, 2002). However, it is important to complement such theoretical frameworks with substantiation of how captivity actually is harmful to nonhuman animals in virtue of the interests they have and how captivity infringes upon such interests. These chapters argue that captivity is fundamentally (and not conditionally) incompatible with the welfare of elephants, whales, and dolphins.If I have one criticism of the book, it is that it could be stronger on certain conceptual issues. Acknowledging its practical and not theoretical focus, it is nonetheless true that if controlling, confining, killing, and causing suffering to nonhuman animals is wrong, then it is important to say something about why it is wrong—even if that explanation amounts to a short synopsis of more theoretical work done elsewhere. While the question of killing is addressed well, the section on the ethics of causing suffering does not address directly why (or under what conditions) causing suffering is wrong. The chapters in this section are worthwhile reading and review practices causing animal suffering in a variety of contexts. Nonetheless, some additional conceptual front matter would have strengthened the section overall.From a conceptual standpoint, the sections on the ethics of control and captivity seem to hang together. Confinement is a form of control and might be argued against on the grounds that it deprives nonhuman animals of opportunities for satisfaction, directly causes physical injury, or causes psychological distress, anxiety, or boredom. These kinds of arguments fit into interest-based accounts of animal welfare, which in turn can be subsumed under a principle of nonmaleficence: We should not cause harm to animals under some specified set of conditions; confinement harms animals in ways x, y, or z; therefore, we should not confine animals in this way.While such interest-based arguments do make an appearance in the text, several of the book's authors also elaborate an autonomy-based argument against control and confinement: Nonhuman animals have their own kind of autonomy, and just as infringing upon the autonomy of paradigmatic persons is wrong, infringing upon nonhuman animals’ autonomy is also wrong. The problem with this argument is that different kinds of autonomy are likely to be at stake. The wrongness of infringing upon paradigmatic persons’ autonomy is often explained by the facts that we are self-conscious, capable of abstract thought (including language use), and capable of intentionally choosing the kind of life that we want to live (e.g., relating to long-term projects or schemes of personal ethics). It could be argued that because nonhuman animals are not capable of exercising this kind of autonomy, they therefore cannot be harmed by its infringement.Some of the book's authors chip away at this presumption, noting (inter alia) that nonhuman animals have desires to move around and do things that are thwarted by confinement or control, that these desires constitute a form of agency, and that (following previous scholarship) nonhuman animals possess some forms of self-awareness. Specifically, the chapters from Valéry Giroux and Carl Saucier-Bouffard, Lori Gruen, and Carlos Naconecy consider such arguments. Naconecy draws upon David DeGrazia's (2009) analysis of animal self-awareness in making his argument. Though the issue deserves more treatment than I can give it here, it seems that nonhuman animals’ autonomy and self-awareness, even if granted, are of a different sort than that possessed by paradigmatic persons. Specifically, (most) nonhuman animals cannot feel wronged by having their preferences overridden because they are not the kinds of beings who are capable of abstractly considering themselves as autonomous and worthy of self-direction. They may desire things, and thwarting these desires might sometimes harm them, but that is a different kind of argument.Infringing upon nonhuman animals’ (more limited kind of) autonomy might nonetheless be wrong, but if different sorts of autonomy are at stake, then moral arguments relating to paradigmatic persons cannot be directly transposed to nonhuman animals. Some additional argument(s) must be supplied, but (on my reading) the book's contributors stop short of this. Nonetheless, as stated above, the ethics of control and questions of nonhuman animals’ autonomy are not as well trod as other issues in animal ethics. Despite my taking issue with some of the details, the discussions contained in the book's first two sections are worthy reading and help to advance the field.Overall, the book's chapters are well written and cogently argued, and given its breadth, different readers will find different things to value in it. The Palgrave Handbook of Practical Animal Ethics is a welcome addition to the literature. (shrink)

One of the central debates within contemporary Anglo-American political philosophy concerns how to formulate an egalitarian theory of distributive justice which gives coherent expression to egalitarian convictions and withstands the most powerful anti-egalitarian objections. This book brings together many of the key contributions to that debate by some of the world’s leading political philosophers: Richard Arneson, G.A. Cohen, Ronald Dworkin, Thomas Nagel, Derek Parfit, John Rawls, T.M. Scanlon, and Larry Temkin.

Michael Stocker and Bernard Williams are recent proponents of the influential objection against utilitarianism that it leads to important forms of alienation. The famous response is that such objections are mistaken. The objections picture agents being motivated by the principle of utility, but, e.g., Peter Railton argues we should see this principle as purely normative – agents can be motivated any way they like and still be ‘objective’ consequentialists. I argue that this type of position is inadequate as a full (...) answer to Stocker and Williams. I trace this failure to his inattention to moral psychology, then show how other remarks made by Mill provide the roots of a better answer to Stocker and Williams. (shrink)

This collection of thirteen essays, when viewed together, offers a unique perspective on the history of American philosophy. It illuminates for the first time in book form, how thirteen major American philosophical thinkers viewed a problem of special interest in the American philosophical tradition: the relationship between experience and reflection. Written by well-known authorities on the figure about which he or she writes, the essays are arranged chronologically to highlight the changes and developments in thought from Puritanism to Pragmatism to (...) Process Philosophy. While Doctrine and Experience will be of particular interest to specialists in American Philosophy, there is also much to offer anyone interested in the intellectual and cultural history of the United States. In order of appearance, the essays are: "Jonathan Edwards and the Great Awakening" by John E. Smith "Heart and Head: The Mind of Thomas Jefferson" by Andrew J. Reck"Emerson and the American Future" by Robert C. Pollock"Chauncey Wright and the Pragmatists" by Edward Madden"Charles S. Peirce: Action Through Thought – The Ethics of Experience" by Vincent G. Potter"Life Is in the Transitions’: Radical Empiricism and Contemporary Concerns" by John J. McDermott"John Dewey and the Metaphysics of American Democracy" by Ralph W. Sleeper"Individualization and Unification in Sartre and Dewey" by Thelma Z. Levine"Josiah Royce: Anticipator of European Existentialism and Phenomenology" by Jacqueline Ann K. Kegley"The Transcendence of Materialism and Idealism in American Thought" by John Lachs"C. I. Lewis and the Pragmatic Tradition in American Philosophy" by Sandra Rosenthal"The Social Philosophy of George Herbert Mead" by David Miller"Existence as Transaction: A Whiteheadian Study of Causality" by Elizabeth Kraus. (shrink)

They say you can’t judge a book by its cover. If that is right, it really is too bad in the case of Andrew Sabl’s Hume’s Politics. It is too bad because the reviewer’s job would be exceedingly easy, and very pleasant. By any measure this book has a strikingly fine cover. Its image is drawn from John Byam Liston Shaw’s depiction of Queen Mary and Princess Elizabeth entering London in 1553. Hume’s interpretation of Elizabeth I plays a (...) prominent role in Hume’s Politics, so I will come back to her. But first, looking beneath the cover, what else does Sabl’s book yield?The short answer is that it yields plenty. There are several important points being... (shrink)

Review of John O'Neill, Alan Holland and Andrew Light, Environmental Values (London: Routledge, 2007 ).

This, the twenty-seventh volume in the annual series of publications by the American Society for Political and Legal Philosophy, features a number of distinguised contributors addressing the topic of criminal justice. Part I considers "The Moral and Metaphysical Sources of the Criminal Law," with contributions by Michael S. Moore, Lawrence Rosen, and Martin Shapiro. The four chapters in Part II all relate, more or less directly, to the issue of retribution, with papers by Hugo Adam Bedau, Michael Davis, Jeffrie G. (...) Murphy, and R. B. Brandt. In the following part, Dennis F. Thompson, Christopher D. Stone, and Susan Wolf deal with the special problem of criminal responsibility in government-one of great importance in modern society. The fourth and final part, echoing the topic of NOMOS XXIV, Ethics, Economics, and the Law , addresses the economic theory of crime. The section includes contributions by Alvin K. Klevorick, Richard A. Posner, Jules L. Coleman, and Stephen J. Schulhofer. A valuable bibiography on criminal justice by Andrew C. Blanar concludes this volume of NOMOS. (shrink)

In recent years, there has been a heated debate about how to interpret findings that seem to show that humans rapidly and automatically calculate the visual perspectives of others. In the current study, we investigated the question of whether automatic interference effects found in the dot-perspective task (Samson, Apperly, Braithwaite, Andrews, & Bodley Scott, 2010) are the product of domain-specific perspective-taking processes or of domain-general “submentalizing” processes (Heyes, 2014). Previous attempts to address this question have done so by implementing inanimate (...) controls, such as arrows, as stimuli. The rationale for this is that submentalizing processes that respond to directionality should be engaged by such stimuli, whereas domain-specific perspective-taking mechanisms, if they exist, should not. These previous attempts have been limited, however, by the implied intentionality of the stimuli they have used (e.g. arrows), which may have invited participants to imbue them with perspectival agency. Drawing inspiration from “novel entity” paradigms from infant gaze-following research, we designed a version of the dot-perspective task that allowed us to precisely control whether a central stimulus was viewed as animate or inanimate. Across four experiments, we found no evidence that automatic “perspective-taking” effects in the dot-perspective task are modulated by beliefs about the animacy of the central stimulus. Our results also suggest that these effects may be due to the task-switching elements of the dot-perspective paradigm, rather than automatic directional orienting. Together, these results indicate that neither the perspective-taking nor the standard submentalizing interpretations of the dot-perspective task are fully correct. (shrink)

Can contemporary American philosophy be characterized in a way which would meaningfully distinguish it from philosophy in other times, other places? The somewhat negative answer to this question given by John E. Smith and Andrew J. Reck is a source of puzzlement to Roger T. Simonds, author of the first essay in this collaboration volume. Simonds asserts, with reference to activism, pragmatism, and optimism, that while "these qualities are... not the exclusive property of American philosophers," yet "Americans seem (...) to show them more than others do," and this is a meaningful characterization because "America herself is a sort of incarnation of Western activism, pragmatism, and optimism." Whether Western philosophy as a whole can profitably take a new point of departure, viz., that of Shankara, the ninth century systematizer of Vedantism, is the question dealt with in the second essay of this volume, written by Cornelia D. Church. Both Shankara and Western philosophers attempt to bring into focus God, the world, man, and mind, but Shankara tries to see how man can be liberated from his limits of perception through a quasi-mystical technique. The possibilities of this avenue for Western seekers of truth, according to Miss Church, "are tremendously exciting.". (shrink)